Fig. 1

Experimental design (A): 5 months old male hAPP-J20 mice and their wild (WT) littermates underwent 5 weeks of whole body vibration intervention (WBV) with twice daily session of 10 min exposure, five times per week (gray color marks the days of treatment). After 5 weeks, balance beam test was performed to assess motor coordination. Animals were terminated on week 6 at the age of ~ 6.5 months and brain tissue was collected for immunohistological analyses. Effects of intervention (pseudo vs. WBV) and genotype (J20 vs. WT) on body weight (B), motor performance (C) and plaque load (D). WT animals showed significatly higher body weight during the intervention compared to the J20 animals (B). Walking distance in the balance beam test was only significantly improved in the J20 animals compared to the WT (C). Amyloid plaque deposition in the hippocampus was not significantly affected by WBV intervention (D). Images of 6e10 were taken about the whole hippocampus at 50 × magnifications to visualze total amyloid plaque distribution (E), representative images of areas marked by + are depicted in D. Data are depicted as mean ± SEM. ** indicates: P < .01. Scale bars in D are 50 um and in E are 500 um