Fig. 3

Behavioral assessments of olfactory function and anxiety- and depression-like phenotype. A Olfactory sensitivity test. Time spent sniffing male feces (p < 0.0001, 0.0037, < 0.0001), female feces (p < 0.0001, 0.0378, 0.0003), vinegar (p = 0.0035, 0.2964, 0.8263) or alcohol (p = 0.0055, 0.0248, 0.4079). B Open field test. Left panel showing representative images of the travelled path. Right panel showing quantitative analysis of the total distance travelled (p < 0.0001, 0.0001, 0.0925) and time spent in the center (p < 0.0001, 0.1251, 0.0007). C Elevated zero maze test. Left panel showing representative images of the travelled path. Right panel showing quantitative analysis of the total distance travelled (p < 0.0001, < 0.0001, 0.0056) and time spent in the open arms (%) (p < 0.0001, < 0.0001, 0.0201). D Forced swim test. Quantitative analysis of immobility time (p < 0.0001, 0.0009, 0.3390). The data are expressed as the mean ± SEM (n = 12 in each group). Two-way ANOVA followed by Tukey’s post hoc test or Scheirer–Ray–Hare test: **p < 0.01