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Fig. 8 | Behavioral and Brain Functions

Fig. 8

From: Naringin provides neuroprotection in CCL2-induced cognition impairment by attenuating neuronal apoptosis in the hippocampus

Fig. 8

Effects of Naringin oncaspase-3, caspase-8,Bax,Bcl-2mRNA expression in the hippocampus of CCL2-treated rats. Quantitative real-time PCR analysis of messenger (m)RNA levels. Relative expression of: a The caspase-3 mRNA. b The caspase-8 mRNA. c The Bax mRNA expression. d The Bcl-2 mRNA. qPCR analysis showed increased expression of caspase-3, caspase-8, Bax mRNA while decreased expression of Bcl-2 in hippocampus of CCL2 rats, This result showing that Naringin significantly decreased expression of caspase-3, caspase-8, Bax mRNA while significantly increased Bcl-2 mRNA in CCL2 group rat.The experiments were repeated four times independently. Values are expressed as mean ± SEM, n = 4 (#P < 0.05, ##P < 0.01 vs sham, *P < 0.05, **P < 0.01 vs CCL2)

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Behavioral and Brain Functions

ISSN: 1744-9081

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