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Table 3 Comparisons of adjusted urinary nicotine concentration and adjusted urinary cotinine concentration among subjects (N = 122) carrying different CYP2A6 and COMT polymorphisms

From: Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men

 

N

Adjusted urinary nicotine, ng/μL median (min–max)

Adjusted urinary cotinine, ng/μL median (min–max)

Model 1

 CYP2A6

  Wild type

17

86.23 (6.14–296.36)

120.90 (20.39–485.32)

  High activity

76

70.45 (6.28–1117.87)

111.08 (8.34–822.11)

  Low activity

29

61.59 (15.28–456.87)

75.87 (10.87–266.44)

  Pa

 

NS

NS

Model 2

 COMT

  COMT rs4680

   Wild type

66

63.86 (6.28–646.38)

92.46 (8.34–506.97)

   Variant

56

67.87 (6.14–1117.87)

118.24 (13.59–822.11)

   Pa

 

NS

0.041

  COMT rs165599

   Wild type

27

68.10 (12.42–212.74)

89.42 (23.06–218.62)

   Variant

95

64.11 (6.14–1117.87)

107.24 (8.34–822.11)

   Pa

 

NS

NS

Model 3

 COMT rs4680/COMT rs165599

  Wild type/wild type

13

89.29 (12.42–212.74)

79.37 (23.06–218.62)

  Wild type/variant

53

63.61 (6.28–646.38)

97.10 (8.34–506.97)*

  Variant/wild type

14

67.87 (15.28–177.61)

95.86 (32.18–202.0)

  Variant/variant

42

69.46 (6.14–1117.87)

122.18 (13.59–822.11)*

  Pa

 

NS

 

Model 4

 COMT rs4680 wild type

  CYP2A6 wild type

9

95.04 (25.04–296.36)

105.70 (53.48–485.32)

  CYP2A6 high activity

39

72.99 (6.28–646.38)

97.45 (8.34–506.97)

  CYP2A6 low activity

18

42.54 (19.38–371.29)

60.20 (10.87–266.44)

  Pa

 

NS

NS

Model 5

 COMT rs4680 variant

  CYP2A6 wild type

8

74.91 (6.14–217.41)

141.53 (20.39–228.68)

  CYP2A6 high activity

37

68.10 (17.68–1117.87)

115.78 (13.59–822.11)

  CYP2A6 low activity

11

66.13 (15.28–456.87)

161.65 (39.19–224.53)

  Pa

 

NS

NS

Model 6

 COMT rs165599 wild type

  CYP2A6 wild type

3

95.04 (62.36–188.57)

102.30 (79.37–120.90)

  CYP2A6 high activity

17

67.64 (12.42–212.74)

89.42 (32.18–218.62)

  CYP2A6 low activity

7

78.05 (15.28–177.61)

63.55 (23.06–202.00)

  Pa

 

NS

NS

Model 7

 COMT rs165599 variant

  CYP2A6 wild type

14

74.92 (6.14–296.36)

141.53 (20.39–485.32)

  CYP2A6 high activity

59

72.99 (6.28–1117.87)

111.09 (8.34–822.11)

  CYP2A6 low activity

22

59.62 (19.38–456.87)

81.66 (10.87–266.44)

  Pa

 

NS

NS

  1. NS not statistically significant
  2. aMann–Whitney U test or Kruskal–Wallis test with Bonferroni adjustment
  3. * Significantly different from the (COMT rs4680 wild-type/COMT rs165599 variant) group versus the (COMT rs4680 variant/COMT rs165599 variant) group by Scheffe’s Post hoc test, P value = 0.022