| N | Adjusted urinary nicotine, ng/μL median (min–max) | Adjusted urinary cotinine, ng/μL median (min–max) |
---|---|---|---|
Model 1 | |||
 CYP2A6 | |||
  Wild type | 17 | 86.23 (6.14–296.36) | 120.90 (20.39–485.32) |
  High activity | 76 | 70.45 (6.28–1117.87) | 111.08 (8.34–822.11) |
  Low activity | 29 | 61.59 (15.28–456.87) | 75.87 (10.87–266.44) |
  Pa |  | NS | NS |
Model 2 | |||
 COMT | |||
  COMT rs4680 | |||
   Wild type | 66 | 63.86 (6.28–646.38) | 92.46 (8.34–506.97) |
   Variant | 56 | 67.87 (6.14–1117.87) | 118.24 (13.59–822.11) |
   Pa |  | NS | 0.041 |
  COMT rs165599 | |||
   Wild type | 27 | 68.10 (12.42–212.74) | 89.42 (23.06–218.62) |
   Variant | 95 | 64.11 (6.14–1117.87) | 107.24 (8.34–822.11) |
   Pa |  | NS | NS |
Model 3 | |||
 COMT rs4680/COMT rs165599 | |||
  Wild type/wild type | 13 | 89.29 (12.42–212.74) | 79.37 (23.06–218.62) |
  Wild type/variant | 53 | 63.61 (6.28–646.38) | 97.10 (8.34–506.97)* |
  Variant/wild type | 14 | 67.87 (15.28–177.61) | 95.86 (32.18–202.0) |
  Variant/variant | 42 | 69.46 (6.14–1117.87) | 122.18 (13.59–822.11)* |
  Pa |  | NS |  |
Model 4 | |||
 COMT rs4680 wild type | |||
  CYP2A6 wild type | 9 | 95.04 (25.04–296.36) | 105.70 (53.48–485.32) |
  CYP2A6 high activity | 39 | 72.99 (6.28–646.38) | 97.45 (8.34–506.97) |
  CYP2A6 low activity | 18 | 42.54 (19.38–371.29) | 60.20 (10.87–266.44) |
  Pa |  | NS | NS |
Model 5 | |||
 COMT rs4680 variant | |||
  CYP2A6 wild type | 8 | 74.91 (6.14–217.41) | 141.53 (20.39–228.68) |
  CYP2A6 high activity | 37 | 68.10 (17.68–1117.87) | 115.78 (13.59–822.11) |
  CYP2A6 low activity | 11 | 66.13 (15.28–456.87) | 161.65 (39.19–224.53) |
  Pa |  | NS | NS |
Model 6 | |||
 COMT rs165599 wild type | |||
  CYP2A6 wild type | 3 | 95.04 (62.36–188.57) | 102.30 (79.37–120.90) |
  CYP2A6 high activity | 17 | 67.64 (12.42–212.74) | 89.42 (32.18–218.62) |
  CYP2A6 low activity | 7 | 78.05 (15.28–177.61) | 63.55 (23.06–202.00) |
  Pa |  | NS | NS |
Model 7 | |||
 COMT rs165599 variant | |||
  CYP2A6 wild type | 14 | 74.92 (6.14–296.36) | 141.53 (20.39–485.32) |
  CYP2A6 high activity | 59 | 72.99 (6.28–1117.87) | 111.09 (8.34–822.11) |
  CYP2A6 low activity | 22 | 59.62 (19.38–456.87) | 81.66 (10.87–266.44) |
  Pa |  | NS | NS |