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Table 1 Distribution of CYP2A6 and COMT polymorphisms

From: Interaction between cytochrome P450 2A6 and Catechol-O-Methyltransferase genes and their association with smoking risk in young men

Genotypes

Current smokers [n = 261 (n%)]

Hardy–Weinberg equilibrium

Never smokers [n = 219 (n%)]

Hardy–Weinberg equilibrium

CYP2A6

 

Pa = 0.713

 

Pa = 0.332

1A/1A

63 (24.1)

 

46 (21.0)

 

1A/1B

100 (38.3)

 

88 (40.2)

 

1B/1B

44 (16.9)

 

31 (14.2)

 

1A/4C

24 (9.2)

 

25 (11.4)

 

4C/4C

4 (1.5)

 

3 (1.37)

 

1B/4C

26 (10.0)

 

26 (11.9)

 

COMT rs4680

 

Pb = 0.003

 

Pb = 0.012

G/G

147 (56.3)

 

113 (51.6)

 

G/A

73 (28.0)

 

69 (31.5)

 

A/A

41 (15.7)

 

37 (16.9)

 

COMTrs165599

 

Pc = 0.966

 

Pc = 0.668

A/A

61 (23.4)

 

45 (20.6)

 

A/G

130 (49.8)

 

112 (51.1)

 

G/G

70 (26.8)

 

62 (28.3)

 
  1. aFor CYP2A6 1A/1A, 1A/1B, 1B/1B
  2. bFor COMT rs4680
  3. cFor COMT rs165599