Figure 1

The MWM room design and the performance of the Saline-injected rats and Tat-injected rats in the MWM. (A) A 3-dimensional representation indicating the position of the platform in the MWM. (B) A simplified schematic diagram indicating the layout and the position of the visual cues present in the room where the pool was located (Pink and Blue lines represent proximal and distal visual cues, the light grey and dark rectangles represent a sink and table respectively, and the small square represents the position of the platform). Arrowheads represent the different release points; (C) The decreasing latency in the Saline-injected rats persisted from pre-injection to post-injection; (D) Latency to find the platform in the MWM was impaired in Tat-injected rats (Results are mean ± SEM). * Post-injection Tat significantly different from pre-injection Tat, p < 0.05. *** Pre-injection trial 1 significantly different from Pre-injection test for the Tat group, p < 0.0001. (Saline: n = 9; Tat: n = 14).