P268S in NOD2 associates with susceptibility to Parkinson’s disease in Chinese population

Table 2 Genotype and allele frequencies of G2385R, P268S, and IVS9 in cases and controls

Genotype	PD patients, n = 237		Control, n = 190		Odds ratio (95% CI)*	p value**	Power^§
	No.	%	No.	%
G2385R(G > A)
GG	213	89.9	186	97.9	1
GA	24	10.1	4	2.1	5.24	0.009	0.8973
GA	24	10.1	4	2.1	(1.79-15.38)	0.009	0.8973
AA	0	0	0	0	—	—
G	450	94.9	376	98.9	1
A	24	5.1	4	1.1	5.01	0.090	0.8803
A	24	5.1	4	1.1	(1.72-14.58)	0.090	0.8803
P268S(C > T)
CC	229	96.6	190	100	1
CT	8	3.4	0	0	—	0.045	NA
TT	0	0	0	0	—	—
C	466	98.3	380	100	1
T	8	1.7	0	0	—	—
IVS9(G > A)
GG	207	87.3	175	92.1	1
GA	30	12.7	15	7.9	1.7	0.348	0.2987
GA	30	12.7	15	7.9	(0.88-3.24)	0.348	0.2987
AA	0	0	0	0	—	—
G	444		365	96.1	1
A	30	6.3	15	3.9	1.64	0.572	0.2865
					(0.87-3.10)

*: Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated by comparison to the common allele frequencies and genotype frequencies.
**: Fisher exact test and false discovery rate were used to calculate and correct the p values, respectively. Two sided P value ≤ 0.05 was considered statistically significant.
^§: Power was calculated by Power and Sample Size Calculations Version 3.0, 2009. NA: not available.

ISSN: 1744-9081