Glutamate (Glu) and glutamine (Gln) levels in neostriatum. n-3 PUFA supplementation modulates Gln/Glu turnover in both male and female SHR rats. Levels of (a) Glu and (b) Gln were used to determine (c) Gln/Glu ratios. Control-fed SHRs of both sexes showed significant ratio reductions when compared to WKY controls, and n-3 PUFA feeding reversed these ratios in both SHR sexes. Data are presented as means ± SEM (n = 4–8) and the level of significance is marked with * (p-value ≤ 0.05), ** (p-value ≤ 0.01) or *** (p-value ≤ 0.001). The p-values are calculated by comparison with the mid bar representing control SHRs.