Dopamine (DA) and homovanillic acid (HVA) levels in neostriatum. n-3 PUFA supplementation modulated DA turnover in male SHR: (a) DA and (b) HVA levels were used to determine (c) HVA/DA ratios. Data are presented as means ± SEM (n = 4–8) and the level of significance is symbolized by * (p-value ≤ 0.05), ** (p-value ≤ 0.01) or *** (p-value ≤ 0.001). The p-values are calculated by comparison with the mid bar representing control-fed SHRs. The analyses were performed by HPLC using electrochemical detection.