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Table 4 Logistic regression analysis of 5HTTLPR gene and 5HT1B receptor gene G861C polymorphism and their interaction for the risk of antisocial alcoholism (AS-ALC)

From: Interaction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism

 

AS-ALC

Models

B

OR

95% CI

P-value

Model 1

    

5HTTLPR low functional group

−0.47

0.62

0.22-1.75

0.37

5HT1B G861C G/C

−0.21

0.81

0.29-2.27

0.69

5HT1B G861C C/C

−1.13

0.32

0.07-1.46

0.14

5HTTLPR low-functional group*5HT1B G861C G/C

1.09

2.97

0.84-10.44

0.09

5HTTLPR low-functional group*5HT1B G861C C/C

1.83

6.22

1.10-35.27

0.04*

Model 2

    

5HTTLPR low-functional group

0.14

1.15

0.43-3.07

0.78

5HT1B G861C G/C

0.49

1.63

0.61-4.35

0.33

5HT1B G861C C/C

−1.26

0.28

0.07-1.19

0.09

5HTTLPR low-functional group*5HT1B G861C G/C

0.07

1.07

0.32-3.65

0.91

5HTTLPR low-functional group*5HT1B G861C C/C

1.75

5.76

1.09-30.44

0.04*

  1. 5HTTLPR low-functional group: S/S, S/L G , L G /L G
  2. 5HTTLPR high-functional group: S/L A , L G /L A , L A /L A , S/XL, L A /XL, L G /XL
  3. B, coefficients; CI, confidence interval; OR, odds ratio
  4. Model 1, reference groups are: 5HTTLPR high-functional group, 5HT1B G861C G/G genotypes, and AS-N-ALC group; covarying for age
  5. Model 2, reference groups are: 5HTTLPR high-functional group, 5HT1B G861C G/G genotypes, and controls; covarying for age
  6. *P < 0.05.
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Behavioral and Brain Functions

ISSN: 1744-9081

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