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Table 6 Reduction of PANSS scores in patients with different GHRL genotypes ( x - ± s )

From: Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients

SNP

Genotype

N

Before treatment

After 8 weeks treatment

Reduction rate (%)*

   

Total**

P a

N b

G c

total

P a

N b

G c

 

rs27647

GG

292

88.06 ± 21.64

24.49 ± 6.63

21.46 ± 8.00

42.11 ± 12.34

45.84 ± 12.63

10.87 ± 3.69

11.65 ± 4.85

23.32 ± 6.33

0.72 ± 0.19

 

GA+AA

88

87.38 ± 23.51

23.05 ± 6.92

22.81 ± 8.28

41.52 ± 13.4

45.40 ± 10.86

10.68 ± 3.53

12.24 ± 5.05

22.48 ± 4.88

0.72 ± 0.19

 

P

 

0.799

0.076

0.169

0.702

0.767

0.672

0.321

0.250

0.988

rs26802

AA

322

88.61 ± 22.47

24.35 ± 6.80

21.74 ± 8.26

42.52 ± 12.76

45.91 ± 12.47

10.90 ± 3.76

11.76 ± 4.97

23.25 ± 6.17

0.72 ± 0.19

 

AC+CC

58

83.97 ± 19.33

23.09 ± 6.16

21.91 ± 7.00

38.97 ± 11.20

44.79 ± 10.85

10.43 ± 2.96

11.93 ± 4.49

22.43 ± 5.15

0.72 ± 0.18

 

P

 

0.140

0.187

0.882

0.048

0.524

0.371

0.805

0.341

0.929

rs696217

GG

253

87.91 ± 22.94

24.23 ± 6.53

21.66 ± 8.36

42.02 ± 13.15

45.09 ± 11.31

10.63 ± 3.60

11.61 ± 4.70

22.85 ± 5.34

0.73 ± 0.18

 

GT+TT

120

87.65 ± 19.38

24.11 ± 6.96

21.82 ± 7.36

41.73 ± 10.91

45.97 ± 11.41

11.01 ± 3.31

11.74 ± 4.70

23.22 ± 6.10

0.71 ± 0.20

 

P

 

0.915

0.870

0.864

0.834

0.484

0.329

0.798

0.555

0.309

rs26311

CC

153

87.25 ± 22.59

24.09 ± 6.84

21.58 ± 7.52

41.58 ± 13.06

45.30 ± 11.10

10.85 ± 3.70

11.52 ± 4.52

22.93 ± 5.35

0.72 ± 0.19

 

GG+GC

223

87.66 ± 21.04

24.09 ± 6.59

21.74 ± 8.36

41.83 ± 11.82

46.01 ± 13.04

10.79 ± 3.63

11.96 ± 5.15

23.25 ± 6.49

0.72 ± 0.19

 

P

 

0.857

0.998

0.845

0.848

0.582

0.884

0.385

0.619

0.883

  1. *reduction rates of PANSS total scores; ** total scores; a Positive score; b negative score; c general pathology score