|
Factors 1 & 2 (behavioral impulsivity)
|
|---|
|
Gene
|
SNP
|
Allele
|
Frequency
|
Model
|
Under/Over Transmitted
|
Inform. Families
|
p-value
|
Power
|
FDR p-value
|
|---|
|
Nominal significance
|
|
BDNF
|
rs7103411
|
C
|
0.20927
|
2
|
O
|
91
|
0.021263
|
9
|
0.10746
|
|
BDNF
|
rs10767664
|
T
|
0.20889
|
2
|
O
|
87
|
0.021492
|
10
|
0.10746
|
|
DRD4
|
rs3758653
|
C
|
0.17287
|
2
|
O
|
52
|
0.008178
|
4
|
0.08178
|
|
HTR1E
|
rs1406946
|
A
|
0.44805
|
1
|
U
|
338
|
0.031630
|
1
|
0.26692
|
|
PNMT
|
rs2934966
|
T
|
0.04997
|
0
|
O
|
102
|
0.027007
|
2
|
0.10349
|
|
TPH2
|
rs6582071
|
A
|
0.22517
|
2
|
U
|
95
|
0.010714
|
10
|
0.10714
|
|
Factors 3 & 4 (cognitive impulsivity)
|
|
Gene wide significance
|
|
PNMT
|
rs200173
|
A
|
0.02383
|
0
|
O
|
40
|
0.003818
|
1
|
0.00936
|
|
PNMT
|
rs200173
|
A
|
0.02383
|
1
|
O
|
40
|
0.004680
|
4
|
0.00936
|
|
Nominal significance
|
|
BDNF
|
rs13306221
|
A
|
0.05762
|
1
|
O
|
140
|
0.042211
|
6
|
0.22758
|
|
DRD1
|
rs686
|
G
|
0.35975
|
0
|
U
|
427
|
0.006978
|
6
|
0.06978
|
|
DRD1
|
rs686
|
G
|
0.35975
|
1
|
U
|
336
|
0.023762
|
8
|
0.11881
|
|
HTR1E
|
rs1406946
|
A
|
0.44805
|
1
|
O
|
338
|
0.034898
|
1
|
0.38387
|
|
HTR2A
|
rs6561333
|
T
|
0.43307
|
2
|
U
|
288
|
0.012237
|
4
|
0.12237
|
|
HTR2A
|
rs1923886
|
C
|
0.41760
|
2
|
U
|
278
|
0.033097
|
5
|
0.16548
|
|
HTR3B
|
rs1672717
|
C
|
0.39106
|
2
|
U
|
234
|
0.040249
|
4
|
0.20125
|
|
HTR3B
|
rs3782025
|
C
|
0.45063
|
2
|
U
|
266
|
0.026497
|
6
|
0.20125
|
|
SLC6A3
|
rs13189021
|
T
|
0.23494
|
2
|
U
|
103
|
0.018997
|
9
|
0.18997
|
|
TPH2
|
rs1352250
|
A
|
0.43298
|
1
|
O
|
359
|
0.011413
|
2
|
0.06598
|
|
TPH2
|
rs10879352
|
T
|
0.39596
|
1
|
O
|
364
|
0.015048
|
4
|
0.06598
|
|
TPH2
|
rs1487275
|
G
|
0.28429
|
1
|
O
|
356
|
0.019794
|
9
|
0.06598
|
- Model: 0 = additive, 1 = dominant, 2 = recessive
- Under/Over Transmitted: O = over-transmitted, U = under-transmitted
