Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population

Table 3 Allele and genotype frequencies of dopamine receptor polymorphisms in patient and control groups.

Locus	Genotype Frequency			χ²	P	Allele Frequency		χ²	P
Taq1B (rs 1079597)	B1B1	B1B2	B2B2	2.0	0.36	B1	B2	0.03	0.86
Cases (n = 212)	0.05(11)	0.41(86)	0.54(115)			0.25(108)	0.75(316)
Controls (n = 196)	0.08(16)	0.36(70)	0.56(110)			0.26(102)	0.74(290)
Taq1D (rs 1800498)	D1D1	D1D2	D2D2	2.49	0.29	D1	D2	0.004	0.95
Cases (n = 211)	0.12(25)	0.58(123)	0.30(63)			0.41(173)	0.59(249)
Controls (n = 195)	0.15(30)	0.51(99)	0.34(66)			0.41(159)	0.59(231)
S311C (rs 1801028)	GG	GC	CC	0.41	0.81	G	C	0.01	0.92
Cases (n = 210)	0.80(169)	0.18(38)	0.10(3)			0.89(376)	0.11(44)
Controls (n = 195)	0.81(159)	0.16(32)	0.02(4)			0.90(350)	0.10(40)
H313H ¹ (rs 6275)	TT	TC	CC	9.60	0.008*	T	C	2.92	0.09
Cases (n = 213)	0.36(76)	0.43(92)	0.21(45)			0.57(244)	0.43(182)
Controls (n = 193)	0.23(44)	0.57(110)	0.20(39)			0.51(198)	0.49(188)
Taq1A ² (rs 1800497)	A1A1	A1A2	A2A2	4.88	0.09	A1	A2	0.57	0.45
Cases (n = 212)	0.08(17)	0.44(93)	0.48(102)			0.30(127)	0.70(297)
Controls (n = 194)	0.15(29)	0.40(77)	0.45(88)			0.35(135)	0.65(253)

¹H313H dominant model (TT Vs TC+CC) P = 0.0045, Odds = 1.879, CI = 1.212 to 2.911
² Taq1A recessive model (A1A1 Vs A1A2+A2A2) P = 0.029, Odds = 0.4960, CI = 0.2632 to 0.9348

ISSN: 1744-9081