Table 3 Interpretation of PPVs and LRs⁺ of APOE alleles and genotypes

> 10

greatly increasing risk for AD

5~ 10

moderately increasing risk for AD

ε 4/ε 4

39.90%

3.76

2~ 5

small increase in risk for AD

ε 4

31.50%

2.60

ε 3/ε 4

28.80%

2.29

1~ 2

minimally increasing risk for AD

15.00% (population prevalence)

1

no change in risk for AD

ε 3

12.00%

0.77

0.5~ 1

minimally decreasing risk for AD

ε 2/ε 4

10.82%

0.69

ε 3/ε 3

9.40%

0.59

ε 2

6.50%

0.39

0.2~ 0.5

small decrease in risk for AD

ε 2/ε 3

5.70%

0.34

0.1~ 0.2

moderately decreasing risk for AD

< 0.1

greatly decreasing risk for AD