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Table 1 Distributions of allele frequencies of APOE and STH gene variations in European-American subjects

From: Variation at APOE and STH loci and Alzheimer's disease

 

APOE alleles

Exact p-values

STH alleles

Exact p-values

 
 

ε 2

ε 3

ε 4

Total

ε 2

ε 3

ε 4

Total

Q

R

Total

  
 

f

n

f

n

f

n

2N

    

f

n

f

n

2N

  

AD

0.024

17

0.617

443

0.359

258

718

0.001

6.0*10-12

2.4*10-18

1.2*10-18

0.767

439

0.233

133

572

0.345

1

EOAD

0.017

6

0.590

203

0.392

135

344

0.002

4.7*10-11

6.8*10-17

2.5*10-17

0.771

216

0.229

64

280

0.506

2

LOAD

0.027

10

0.644

237

0.329

121

368

0.022

3.6*10-7

3.1*10-11

5.5*10-11

0.762

218

0.238

68

286

0.348

2

FH+

0.014

5

0.590

204

0.396

137

346

6.8*10-4

4.9*10-11

2.1*10-16

2.3*10-17

0.737

205

0.263

73

278

0.094

2

FH-

0.030

11

0.641

232

0.329

119

362

0.051

2.2*10-7

4.1*10-11

1.1*10-10

0.796

226

0.204

58

284

1.000

2

Male

0.032

9

0.635

179

0.333

94

282

0.093

3.9*10-5

1.7*10-7

3.9*10-7

0.738

155

0.262

55

210

0.145

3

Female

0.018

8

0.606

264

0.376

164

436

0.008

7.0*10-8

9.8*10-12

4.9*10-12

0.785

284

0.215

78

362

1.000

3

Controls

0.061

30

0.801

394

0.138

68

492

    

0.794

313

0.206

81

394

  

Male

0.065

15

0.800

184

0.135

31

230

    

0.805

140

0.195

34

174

  

Female

0.057

15

0.802

210

0.141

37

262

    

0.786

173

0.214

47

220

  
  1. f, frequency; n, number of alleles; N, number of individuals; 2N, number of chromosomes; AD, Alzheimer's disease; EOAD, early-onset AD (≤70yrs); LOAD, late-onset AD (>70yrs); Controls, the total controls combining two subgroups through two different diagnostic evaluations. The numbers in last column denote: 1. Comparing overall AD with controls (α was set at 0.017 for each APOE allele comparison); 2. Comparing EOAD, LOAD, FH+AD and FH-AD with controls respectively (α was set at 0.003 for each APOE allele comparison); 3. Comparing male AD with male controls and female AD with female controls (α was set at 0.003 for each APOE allele comparison).