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Figure 2 | Behavioral and Brain Functions

Figure 2

From: Methylphenidate improves prefrontal cortical cognitive function through α2 adrenoceptor and dopamine D1 receptor actions: Relevance to therapeutic effects in Attention Deficit Hyperactivity Disorder

Figure 2

The enhancing effects of methylphenidate were blocked by co-administration of the α2 adrenoceptor antagonist, idazoxan at a dose which had no effect on its own. Results represent mean ± S.E.M. percent correct on the delayed alternation task. VEH = cracker vehicle; MPH = optimal dose of methylphenidate (1.0–2.0 mg/kg); IDA = idazoxan (0.1 mg/kg); ** significantly different from VEH, p = 0.002; † significantly different from MPH, p = 0.003.

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